benzhydrocodone/acetaminophen and pentobarbital each improve sedation. Avoid or Use Alternate Drug. Restrict use to clients for whom alternative therapy solutions are insufficient

pentobarbital will reduce the extent or effect of nisoldipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will lessen the level or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Observe sufferers presently on buprenorphine subdermal implant who have to have freshly-initiated treatment method with CYP3A4 inducer for signs and symptoms of withdrawal.

pentobarbital will lower the extent or effect of bazedoxifene/conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will decrease the level or effect of hydrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will minimize the level or effect of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lessen the level or effect of isradipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.

pentobarbital will lessen the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.

lasmiditan, pentobarbital. Either check here boosts effects with the other by sedation. Use Caution/Keep track of. Coadministration of lasmiditan and other CNS depressant drugs, like alcohol have not been evaluated in clinical studies. Lasmiditan might lead to sedation, together with other cognitive and/or neuropsychiatric adverse reactions.

pentobarbital and daridorexant the two raise sedation. Modify Therapy/Keep an eye on Carefully. Coadministration increases risk of CNS depression, which may result in additive impairment of psychomotor functionality and trigger daytime impairment.

Contraindicated (1)pentobarbital will decrease the level or effect of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will increase effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers may possibly maximize metabolism of ifosfamide to its metabolite. Monitor for improved effects/toxicities if combined with CYP2B6 inducers.

pentobarbital will reduce the level or effect of conivaptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

pentobarbital will reduce the extent or effect of eucalyptus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.